1- cardiac drugs:
A- Digitalis (impregnation):
* PR Elongation
* ST cup Aspect
* Flattening or negativity of the T wave
* A moderately increased amplitude U
* QT shortening
B- Quinidine:
* PR Elongation
* Moderate Expansion of QRS
* Sub-ST segment elevation; Flat or negative T
* Increased U
* QT Prolongation
C- Amiodarone:
* Bradycardia; elongation RA
* Wave bifid or crocheted T “camel”
* An increased U wave
* QT Prolongation
D- Broadening the PR:
* Amiodarones, quinidine, digalliques
* Calcium channel blockers (bepridil also lengthens the QT)
2- non-cardiac drugs:
A- Psychotropic:
Repolarization abnormalities kind of quinidine; tricyclics determine flattening or inversion of the T wave and increase U.
B- Pest Control:
Emetine, antimony, chloroquines cause flattening or inversion of the wave very durable T (weeks or months)
C- antimitotic:
Adriamycin can give repolarization abnormalities; SF-uracil gives a shift-addition of ST and T negativity with heart pain
+ The QT prolongation (especially hypokalemia) exposed to a risk of torsades de pointes.
Erythromycin + IV can cause QT prolongation with risk of torsade de pointes.
