Medical News

Verneuil’s disease

Par

15 February 2023

5453

I – Introduction:

A- Definition of Verneuil’s disease:

B- Importance of the disease:

Verneuil’s disease is a chronic, painful and disabling pathology that can significantly affect the quality of life of patients. Symptoms such as pain, discomfort and suppuration can limit daily activities, lead to reduced mobility and reduced self-esteem. Psychological impacts are also significant, ranging from anxiety and depression to social isolation. Although Verneuil’s disease is considered a rare disease, estimates of its prevalence vary widely, ranging from 1 to 4% of the population. It is important to note that Verneuil’s disease is often underdiagnosed and misunderstood, which can lead to delays in treatment and deterioration in quality of life. As a result,

C- Objective of the article:

The purpose of this article is to raise awareness about Verneuil’s disease, a chronic skin condition that is often underdiagnosed and misunderstood. We will discuss symptoms, risk factors, causes, and available treatments to help patients better understand this disease and take charge of their health. We will also address the psychological and social impacts of Verneuil’s disease and discuss practical advice to improve patients’ quality of life. Finally, we hope that this article will help raise awareness of this disease among the public and healthcare professionals and improve patient care, by providing them with accurate and up-to-date information to better understand and manage their condition.

II- What is Verneuil’s disease?

A- Definition and symptoms:

Verneuil’s disease, also called hidradenitis suppurativa, is a chronic inflammatory disease of the skin characterized by the formation of nodules, abscesses and fistulas in specific areas of the body, such as the armpits, groin, buttocks , breasts and genitals. Symptoms of Verneuil’s disease vary depending on the severity of the disease and may include throbbing pain, inflamed nodules and abscesses, suppuration and unpleasant odors. The lesions can be chronic and tend to grow slowly. Patients with Verneuil’s disease may also experience itching, burning, and increased tenderness in the affected areas. In severe cases, Verneuil’s disease can cause scarring, fibrosis and impaired functionality. Although Verneuil’s disease is often associated with poor hygiene or being overweight, it is actually caused by problems with inflammation and the immune system. Symptoms of Verneuil’s disease can have a significant impact on quality of life, and it’s important to see a dermatologist for proper diagnosis and treatment.

B- Risk factors:

Although Verneuil’s disease can affect anyone, there are several risk factors that can increase a person’s chance of developing this condition. Risk factors include age (patients with Verneuil’s disease are typically between the ages of 20 and 40), gender (women are more likely to develop this disease than men), obesity, smoking, poor hygiene and a family history of the disease. Patients with certain autoimmune diseases, such as Crohn’s disease and rheumatoid arthritis, may also be at higher risk of developing Verneuil’s disease. The precise risk factors are not yet well understood, but Verneuil’s disease is thought to be caused by problems with inflammation and the immune system. It is important for patients at risk to watch for symptoms of Verneuil’s disease and see a dermatologist for proper diagnosis and treatment. Early diagnosis can help prevent complications and improve patients’ quality of life.

C- Diagnosis:

Diagnosing Verneuil’s disease is often difficult and can take time because the symptoms are similar to many other skin diseases. An accurate diagnosis is important to ensure proper treatment and to avoid complications. The dermatologist will begin by performing a physical examination of the affected areas, looking for nodules, abscesses, fistulas, and scars. The patient’s medical history, including family history, can also help confirm the diagnosis. In some cases, laboratory tests may be done to rule out other illnesses or to confirm the diagnosis, such as bacterial cultures or skin biopsies. Although Verneuil’s disease is not curable, early diagnosis can help prevent complications and improve patients’ quality of life. It is important to see a dermatologist if you suspect Verneuil’s disease or if you experience any unusual or persistent skin symptoms in the affected areas.

III- Causes of Verneuil’s disease:

A- Theories on the causes:

The exact causes of Verneuil’s disease are unknown, but recent research suggests that it is linked to problems with inflammation and the immune system. Some experts believe that Verneuil’s disease is caused by an abnormal inflammatory response of the immune system to a bacterial infection. Other theories suggest that the disease is caused by malfunctioning hair follicles and sweat glands, which can lead to the formation of nodules and abscesses. Obesity and smoking have also been linked to Verneuil’s disease, although the nature of this association is still poorly understood. Some patients with Verneuil’s disease also have a family history of the disease, which suggests a possible genetic component. At the end of the day, the exact cause of Verneuil’s disease is likely multifactorial, involving environmental, genetic, and immunological factors. Further research is needed to better understand the causes of this disease and to develop more effective treatments.

B- Genetic factors:

Verneuil’s disease is considered a complex disease that is influenced by many factors, including genetic factors. Although no specific gene has been identified as responsible for Verneuil’s disease, studies have shown that it can be passed on inheritably, suggesting a possible genetic predisposition. A family history of the disease has been reported in approximately one-third of patients with Verneuil’s disease. However, disease transmission does not follow a single genetic inheritance pattern, suggesting that there could be multiple genes involved. Twin studies have also shown that Verneuil’s disease has a strong genetic component, as it is more common in identical twins than in non-identical twins. Although genetics is not the only cause of Verneuil’s disease, it can play an important role in predisposing to the disease. Further research is needed to better understand the role of genetic factors in the development of this disease and to develop more effective treatments.

C- Environmental factors:

Environmental factors may also play a role in the development of Verneuil’s disease. Obesity and smoking have been identified as possible risk factors. Patients with Verneuil’s disease tend to have a higher body mass index (BMI) than the general population, and obesity is associated with more severe cases of the disease. Smoking can also make Verneuil’s disease worse because it can disrupt sweat glands and hair follicles. Other environmental factors may also play a role in disease development, such as stress, repetitive skin trauma, skin infections, and hormonal disruptions. It is important for patients with Verneuil’s disease to take steps to minimize environmental factors that can make their disease worse, such as losing weight, quitting smoking, and avoiding repetitive trauma to the skin. Further research is needed to better understand the impact of environmental factors on the development of Verneuil’s disease and to develop more effective prevention strategies.

IV- Treatment of Verneuil’s disease:

A- Medical care:

The medical management of Verneuil’s disease is often difficult, because there is no definitive curative treatment. However, there are treatments to relieve symptoms, prevent complications, and improve patients’ quality of life. Basic treatment often consists of hygienic measures and local medications, such as antiseptics, topical antibiotics and corticosteroids. Oral antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids may be prescribed for more severe pain and inflammation. In the most severe cases, surgery may be needed to remove lesions and infected tissue. Medical care must be individualized according to the severity of the disease, the location of the lesions and the patient’s medical history. It is also important that patients receive psychological support to cope with the consequences of this chronic and debilitating disease. Multidisciplinary care involving dermatologists, surgeons, specialist nurses and psychologists can help improve the quality of life of patients with Verneuil’s disease.

B- Surgical management:

Surgical management of Verneuil’s disease is often reserved for the most severe cases, where the lesions are large, recurrent and painful, and do not respond to medical treatments. The goal of surgery is to reduce pain, improve function, and prevent disease recurrence. Surgical procedures can vary depending on the location, size and complexity of the lesions. In some cases simple excision of the lesions is sufficient, while in other cases a more invasive procedure may be required, such as incision and drainage of abscesses, deep excision of the skin and tissues beneath -lying, or even a skin graft. The most recent surgical techniques use lasers and light-based treatments to destroy the hair follicles, which are the source of the disease. However, these techniques are still being evaluated and are not available everywhere. Although surgery can improve the symptoms of Verneuil’s disease, it is important to note that it does not guarantee a complete cure, and the lesions may reappear after surgery. Therefore, surgery should be considered as a long-term option as part of a comprehensive management of Verneuil’s disease. Although surgery can improve the symptoms of Verneuil’s disease, it is important to note that it does not guarantee a complete cure, and the lesions may reappear after surgery. Therefore, surgery should be considered as a long-term option as part of a comprehensive management of Verneuil’s disease. Although surgery can improve the symptoms of Verneuil’s disease, it is important to note that it does not guarantee a complete cure, and the lesions may reappear after surgery. Therefore, surgery should be considered as a long-term option as part of a comprehensive management of Verneuil’s disease.

C- Complementary treatments:

In addition to medical and surgical management, complementary treatments can be used to relieve symptoms and improve quality of life for patients with Verneuil’s disease. These complementary treatments may include alternative therapies such as acupuncture, hypnosis, meditation, relaxation therapy and herbal medicine. Patients can also benefit from psychological support, including support groups for people with Verneuil’s disease. Dietary and lifestyle changes, such as reducing alcohol intake, smoking, and stress may also be beneficial. Complementary treatments should be used in conjunction with appropriate medical and surgical treatments and should be discussed with a qualified healthcare professional prior to use. Although there is no cure for Verneuil’s disease, the use of complementary treatments can help reduce pain, improve quality of life, and increase the general well-being of patients.

V- Living with Verneuil’s disease:

A- Tips to improve the quality of life:

Verneuil’s disease can have a significant impact on patients’ quality of life, both physically and mentally. However, there are tips and steps that patients with Verneuil’s disease can take to improve their quality of life. First, it is important to follow the medical and surgical treatments prescribed by a qualified medical professional to help manage the condition. Patients may also benefit from modifying their diet, avoiding spicy, fatty, or acidic foods, which can worsen symptoms of Verneuil’s disease. Patients should also avoid smoking, as it can aggravate the disease and slow healing. Finally, it is important to seek emotional and social support, whether it’s with support groups for patients with Verneuil’s disease or talking to friends and family. By taking these steps, patients with Verneuil’s disease can improve their quality of life and find ways to manage the disease long-term.

B- Psychological support:

Psychological support is an important part of the management of patients with Verneuil’s disease. The disease can have a significant impact on patients’ quality of life, resulting in pain, physical limitations and altered self-image. It is important that patients receive emotional support to cope with the emotional effects of the disease, such as anxiety, depression and shame. Support groups for patients with Verneuil’s disease can help patients connect with others living with the disease, share experiences, and receive advice and support. Patients may also benefit from individual or couple therapy to manage the emotional effects of the illness, such as depression, anxiety and relationship problems. Qualified healthcare professionals can help patients find the appropriate psychological support and develop a treatment plan that suits their individual needs. By receiving adequate psychological support, patients with Verneuil’s disease can improve their quality of life and learn to manage the emotional effects of the disease.

C- Prevention of complications:

Verneuil’s disease can be associated with many complications, including infections, abscesses, and fistulas. Preventing these complications is important to help patients manage their disease and improve their quality of life. To prevent infections, patients with Verneuil’s disease should keep affected areas clean and avoid friction, pressure, and trauma. Patients should also avoid puncturing lesions or abscesses and touching them with unwashed hands. If an infection does occur, it is important to treat it promptly with antibiotics prescribed by a qualified medical professional. Patients may also benefit from regular monitoring of their disease by a medical professional to detect signs of complications and treat them promptly. Finally, patients can also make healthy lifestyle changes, such as exercising regularly, eating healthy, and avoiding smoking, to help prevent complications from Verneuil’s disease.

VI- Conclusion:

A- Summary of key points:

Verneuil’s disease is a chronic inflammatory disease of the skin that manifests as painful nodules, abscesses and fistulas. It can affect patients’ quality of life, leading to pain and physical limitations. Risk factors include smoking, obesity, high blood pressure, and a family history of the disease. Diagnosis is usually made by clinical observation and histological examination. Treatment can include medical options such as antibiotics, anti-inflammatories, corticosteroid injections, as well as surgical options such as incision and drainage of abscesses and plastic surgery procedures. Complementary treatments such as phototherapy, homeopathic remedies and diet changes may also be beneficial. Patients may also benefit from psychological support to cope with the emotional effects of the disease and regular monitoring to prevent complications. In summary, Verneuil’s disease requires multidisciplinary management to improve the quality of life of patients and prevent complications.

B- Prospects for the future:

Research on Verneuil’s disease is ongoing and many advances have been made in recent years. The most promising advances relate to the development of new drugs targeting the inflammatory cytokines implicated in the disease. Biological treatments such as interleukin-1 and interleukin-17 inhibitors have shown encouraging results in clinical trials. Other emerging treatments include immunotherapies and gene therapies. In addition, in-depth genetic studies will allow a better understanding of the pathogenesis of the disease and how it is passed down in families. Finally, a better awareness of Verneuil’s disease, combined with a better understanding of the pathology, should make it possible to improve early diagnosis, treatment and quality of life for patients. Although Verneuil’s disease is currently incurable, these developments offer hope for the future of research into this crippling disease.

C- Call to action and awareness:

Verneuil’s disease is a chronic disabling disease that affects the quality of life of millions of people around the world. However, the disease often remains misdiagnosed, misunderstood and poorly managed. This is why it is important to educate patients, health professionals and the general public about Verneuil’s disease. In particular, healthcare professionals need to be better trained to recognize disease symptoms and provide early treatment to improve clinical outcomes and quality of life for patients. Patients with the disease should also be informed of the treatment options and support resources available to them. Finally, greater investment in research is needed to understand the underlying causes of Verneuil disease and develop more effective treatments. Together, we can improve the quality of life for people with Verneuil’s disease by raising awareness and investing in research.